Lg Chemical Ltd.

Hyun Ho Chung

Jong Sung Koh

Jong Hyun Kim

Seong Gu Ro

Tae Hwan Kwak

Hyun Il Lee

Sun Hwa Lee

In Ae Ahn

You Seung Shin

Hyun Sung Kim

Won Hee Jung

Tae Saeng Choi

Kwi Hwa Kim

Jin Ho Lee

Shin Wu Jeong

Jung Kwon Yoo

Sang Woong Kim

You Seong Shin

Chung Mi Kim

Ki Won Park

Kyung Duk Moon

Young Hoon Oh

The present invention relates to novel imidazole derivatives which show an inhibitory activity against farnesyl transferase, pharmaceutically acceptable salts or isomers thereof and pharmaceutical compositions comprising such imidazole derivatives. More particularly, the present invention relates to intermediate compounds which are used in the preparation of the imidazole derivatives of the invention. Related processes also are disclosed.

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1): and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof

The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R , R , R and R are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.

Hydantoin compounds and methods related thereto

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n,and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

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Daejeon, South Korea

Hyun Ho Chung