Korea Advanced Institute of Science and Technology

Enhancedbio Inc.

Skhynix Inc.

Ewha University-Industry Collaboration Foundation

Innotherapy Inc.

Hyukjin Lee

Haeshin Lee

Minjeong Kim

Michaela Jeong

Hansaem Jeong

Yunmi Seo

SeongHwan Cho

Ho Yeon Lee

Tae Gwan Park

Hyokyoung Kwon

Moon Sue Lee

Kyunghyun Kim

In Taek Song

Il Young Jung

Jino Seo

The present invention relates to lipid nanoparticles for in vivo drug delivery and uses thereof, and the lipid nanoparticle are liver tissue-specific, have excellent biocompatibility and can deliver a gene therapeutic agent with high efficiency, and thus it can be usefully used in related technical fields such as lipid nanoparticle mediated gene therapy.

Ionizable lipid compounds, lipid nanoparticles comprising same and therapeutic uses thereof

A semiconductor device includes a memory cell array including a plurality of memory cells coupled between a multiplicity of word lines and one or more bit lines; and an operation circuit configured to perform a multiplication and accumulation (MAC) operation with one or more first multi-bit data provided from the one or more bit lines and one or more second multi-bit data, wherein a plurality of memory cells coupled to a bit line store a plurality of bits included in a corresponding one of the one or more first multi-bit data, and wherein the memory cell array sequentially provides the plurality of bits included in the corresponding first multi-bit data to the operation circuit.

Semiconductor device including a memory array performing a multiplication and accumulation (MAC) operation using capacitors

Lipid nanoparticles for in-vivo drug delivery, and uses thereof

The present invention provides facile and accurate molecular diagnosis of disease-specific genes capable of the naked eye detection through amplifying the target genes to selectively block the fluid path in a microfluidic device. Specifically, the present invention includes an isothermal amplification of target genes through a rolling circle amplification, a microfluidic device for detecting pathogen genes, and a detection method using the same. Therefore, the present invention can conveniently detect a single target gene, such as a single pathogen, or at the same time, several target genes, such as several pathogens, without complicated mechanical equipment.

Microfluidic device for detecting target gene, method for manufacturing same, and method for detecting using same

The present invention relates to a conjugate of a protein or peptide with a polyethylene glycol derivative having catechol, wherein the protein or peptide is mono-PEGylated at the N-terminal with the polyethylene glycol derivative, and to a preparation method thereof. According to the invention, the catechol-PEG derivative can be site-specifically conjugated with the N-terminal amine group of a protein or peptide, so that a homogeneous polyethylene glycol-protein or -peptide conjugate can be obtained in high yield. Unlike a prior art conjugate, the conjugate obtained according to the invention allows the decrease in the activity of the protein to be minimized without chemically modifying the protein, and thus the conjugate has an excellent pharmacological effect. Also, because the conjugate is homogeneous, the process for preparing the conjugate can be simplified. Moreover, the conjugate has uniform biological efficacy in vivo and shows strong resistance to hydrolysis and thus a long in vivo duration time. Accordingly, the conjugate has the effect of increasing the in vivo efficacy and stability of the protein drug.

Conjugate of catechol-modified polyethylene glycol with protein or peptide and preparation method thereof

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Seoul, South Korea

Hyukjin Lee