University of California

University of Rhode Island Research Foundation

Hyuakjae Choi

William H Gerwick

David C Rowley

Jennifer Smith

Lena Gerwick

Francisco Villa

The invention provides novel compositions based on a structure designated as 'Honaucin A', including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.

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Hyuakjae Choi