Emulate, Inc.

Hyoungshin Park

Geraldine A Hamilton

Catherine Karalis

Daniel Levner

Christopher David Hinojosa

Norman Wen

Antonio Varone

Jacob Fraser

Justin Nguyen

Riccardo Barrile

David Conegliano

Andries Van Der Meer

Monicah Otieno

Sauveur Jeanty

Kyung-Jin Jang

Josiah Daniel Sliz

Ananth Nookala

Sushma Jadalannagari

Janey Ronxhi

Gang Luo

Sonalee Barthakur

Brian Zuckerman

Tanvi Shroff

Ville Kujala

Donald Mckenzie

The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.

Microfluidic proximal tubule kidney-on-chip

The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.

Microfluidic kidney-on-chip

Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it 'on-chip' before moving into the experimental region of the chip.

Additive channels

Growing community of inventors

Newton, MA, United States of America

Hyoungshin Park