Korea Ocean Research and Development Institute

Korea Institute of Ocean Science & Technology

Korea Institute of Science and Technology

Korea Ocean Research Institute

Hyoung Seok Lee

Joung Han Yim

Se Jong Han

Il Chan Kim

Tai Kyoung Kim

Ha Ju Park

Pil-Sung Kang

Heeyong Park

Sung Jin Kim

Doc Kyu Kim

Mi Ra Park

Dong-Gyu Jo

Jung Eun Kim

Hyun Cheol Oh

Bhattarai Hari Datta

Cheolsoon Lee

Keun-Sik Kim

Pyung Cheon Lee

Yu-Kyung Park

Dockyu Kim

Hari Datta Bhattarai

Sung Gu Lee

Jae Won Kim

Ki Hyuk Yoon

Dong Gyu Lee

Sung Kyu Kim

Su-Geun Yang

Yu-Kyeong Park

Suhkneung Pyo

Seung Jin Kim

Babita Paudel-Bhattarai

Lee Don Hang

Keun Sik Kim

Hye Yeon Koh

Jong Han Yim

Ii Chan Kim

Provided is a three-dimensional (3D) image display apparatus using laser beam scanning (LBS) projection optical systems. The 3D image display apparatus includes a plurality of LBS projection optical systems arrayed in horizontal and vertical directions, an input unit through which a 3D image signal is input, and an image signal controller configured to distribute the 3D image signal input through the input unit to the LBS projection optical systems. Each of the arrayed LBS projection optical systems has a beam-projection center point for outputting light to an outside of the LBS projection optical system, and an image projected from the beam-projection center point is a horizontal-parallax image based on the beam-projection center point.

Three-dimensional image display apparatus using laser beam scanning projection optical systems

The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-&#x3ba;B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin

There is provided a novel use of ramalin for preventing or treating liver diseases, and more specifically, a pharmaceutical composition for preventing or treating hepatic fibrosis or cirrhosis containing ramalin or a pharmaceutically acceptable salt thereof, and a functional food containing the same. It was confirmed that at the time of applying ramalin, which is a compound derived fromaccording to the present invention, to animal models, ramalin may remarkably suppress hepatic fibrosis and lower liver cirrhosis levels as compared to silymarin known as a liver cell protecting ingredient without cytotoxicity to normal liver cells, such that ramalin may be effectively used for preventing or treating hepatic fibrosis and liver cirrhosis.

Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin

Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.

Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group

The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

Method for preparing ramalin

The present invention relates to pharmaceutical and food compositions for preventing or treating diabetes or obesity, and more particularly to pharmaceutical compositions and functional foods for preventing or treating diabetes or obesity, which contain, as an active ingredient, a novel compound synthesized from a compound separated from an extract of the. The novel compounds of the invention have very excellent PTP-1b (protein tyrosine phosphatase-1b) inhibitory activities, act selectively only on PTP-1b among protein tyrosine phosphatases, and are substantial PTP-1b inhibitors which are effective in preventing or treating diabetes or obesity.

Pharmaceutical and food compositions for preventing or treating diabetes or obesity

Growing community of inventors

Seoul, South Korea

Hyoung Seok Lee