Korea Institute of Science and Technology

Hyoung Ja Kim

Yong Sup Lee

Chang Bae Jin

Jae Yeol Lee

Hokoon Park

Hyun Beom Lee

Jungsook Cho

Mijeong Park

Hyun Soo Choi

Yunaaon Song

Min Jeoung Son

Chang Soo Yook

Changbae Jin

You Bin Cho

Disclosed are aalcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from aethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, thealcoholic extract and the solvent fractions or the novel compounds 1 and 2.

Food compositions and pharmaceutical compositions containingextract for lowering blood cholesterol levels and for ameliorating atherosclerosis

The present invention relates to anextract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment, prevention and improvement of hyperuricemia or gout. Theextract, the fraction thereof and 6'-O-caffeoylampelopsisionoside, 6&#x2032;-O-caffeoylroseoside, 6&#x2032;-O-caffeoylsonchuinoside C, 6&#x2032;-O-caffeoyldihydrosyringin and glehnoside as the active compounds isolated from the fraction according to the present invention have substantial effect of inhibiting production of uric acid and decreasing its concentration. Accordingly, theextract, the fraction thereof and the active compounds isolated therefrom the fraction according to the present invention can be effectively used as an active ingredient of a drug, health food, etc. for the treatment, prevention and improvement of such as hyperuricemia or gout, which are diseases induced by increased level of uric acid.

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An ethyl acetate extract of-and compounds isolated therefrom for preventing and treating brain diseases such as Alzheimer's disease, stroke and Parkinson's disease, cell and tissue damage caused by ischemia, or cardiovascular system disease such as myocardial infarction.

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Seoul, South Korea

Hyoung Ja Kim