Korea Research Institute of Bioscience and Biotechnology

Korea Institute of Oriental Medicine

Hyouk Joung

Kyung Seop Ahn

Sei Ryang Oh

Hyeong Kyu Lee

Doo Young Kim

Mi Jin Kim

Joong Ku Lee

Ok Kyoung Kwon

Bo Young Park

Sang Ku Lee

Gui Hua Quan

Sang Woo Lee

Ok-Kyoung Kwon

Joongku Lee

Wan Yi Li

Hang Jin

Kyoung-youl Lee

Hwa-Young Son

Mee-Young Lee

Jung Won Youm

Inhee Mook

Hyun Soon Kim

Mi Sun Kim

Jae Heung Jeon

The present invention relates to a composition comprising an extract ofgenus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract ofgenus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

[object Object]

A pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract ofas an active ingredient. The extract ofof the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-&#x3b1; in macrophages. Therefore, the extract ofof the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity

The present invention relates to a composition comprising an extract ofgenus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract ofgenus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

The present invention relates to a transformed plant cell expressing &#x3b2;-amyloid gene, which is known as a causal substance of senile dementia in human, a transformed plant and a preparation method of the same, more particularly, to a transformed plant cell expressing tandem repeats of &#x3b2;-amyloid gene, a transformed plant produced by tissue-culturing the above cells and a preparation method of the same. The transformed plant of the present invention expresses multiple &#x3b2;-amyloid protein, so that the plant can be effectively used for the preparation of an oral vaccine composition for the prevention of senile dementia in human.

Transformed plant cell expressing tandem repeats of beta-amyloid gene and plant produced by the same

Growing community of inventors

Daejeon, South Korea

Hyouk Joung