Daewoong Pharmaceutical Co., Ltd.

Hyo Shin Kim

Sun Ah Jun

Ji Duck Kim

Myunggi Jung

Hyung Geun Lee

Jun Hee Lee

Min Hee Cho

In Woo Kim

Ha Young Kim

Chun Ho Lee

Yun Soo Yoon

Ji Sung Yoon

Yun Soo Na

Min Jae Cho

Il-Hwan Kim

Inwoo Kim

Hyung-Geun Lee

Kyung Ha Chung

Sung-Young Kim

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers

The invention relates to a compound represented by Chemical Formula 1, below, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the compound or salt. The compound of the invention or pharmaceutically acceptable salts thereof can be used for the prevention or treatment of sodium channel blocker-related diseases. 

Substituted benzenesulfonamides as sodium channel blockers

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers, preparation method thereof and use thereof

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Yeonsu-gu, South Korea

Hyo Shin Kim