Yuhan Corporation

Hyo-Ick Hwang

Ji-Hye Choi

Sang-Ho Oh

Doo-Byung Lee

Kyoung-Chan Kwon

Sung-Hee Cho

Sang-Won Kim

Su-Young Lee

Ik-Su Jo

Kyeong-Sill Lee

Provided are a process for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof, which is an intermediate useful for the preparation of tofacitinib, an intermediate used in the process, i.e., isopropanol solvate of methyl ((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)carbamate dibenzoyl-L-tartrate, an intermediate, having excellent stability, useful for the preparation of tofacitinib, i.e., (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine acetate, and a process for preparing tofacitinib or a pharmaceutically acceptable salt thereof.

Processes for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same

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Suwon-si, South Korea

Hyo-Ick Hwang