Korea Institute of Science and Technology

Hyewhon Rhim

Ae Nim Pae

Seon Hee Seo

Dong Jin Kim

Yong Seo Cho

Hyunah Choo

Kyung Il Choi

Hee Sup Shin

Eun Joo Roh

Jae Kyun Lee

Kye Jung Shin

Ghilsoo Nam

Hye Jin Chung

Youngsoo Kim

Taehyun Kim

Hun Yeong Koh

Gyo Chang Keum

Yong Koo Kang

Joo Hwan Cha

Eunice Eun-Kyeong Kim

Key-Sun Kim

Ye Sun Han

Hesson Chung

Hoh Gyu Hahn

Dong Yun Shin

Kee Dal Nam

Yoon Jee Kim

Woong Seo Park

Chan Seong Cheong

Hye Ran Kim

Kee Hyun Choi

Wook Hwan Kim

Yun Kyung Kim

Ji Yoon Kang

Soo Hyun Lee

Soon Bang Kang

Jae Yeol Lee

In-sung Choi

Yong Sup Lee

Chi Man Song

Hyewon Seo

Dae-Sik Lim

Juhyun Choi

Kyung-Il Choi

Cheolju Lee

Seong-Woo Jeong

Jung-Ha Lee

Byong-Gon Park

Edward Perez-Reyes

Hwa-Sil Kim

Sunoh Kim

Hun Yeoung Koh

Jung Ho Back

Yi Jae Lee

Hyung Kook Lee

You Na Oh

The present disclosure relates to a system for monitoring post-translational modification of protein using a biosensor with a gap, which performs with high reliability a diagnosis of a disease associated with a target protein for which impedance is measured, by measuring an impedance of a sample introduced into a sensor and calculating a change rate of the measured impedance, and to a method of manufacturing the biosensor used for the system.

System for monitoring post-translational modification of protein using bio-sensor with gap and manufacturing method for bio-sensor

Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof

The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof

Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. 

Isoindolinone derivatives having inhibitory activity against T-type calcium channel and method for preparation thereof

Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. 

Phenylacetate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for prevention or treatment of diseases induced by activation of T-type calcium ion channel containing the same as an active ingredient

The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type &#x3b1;1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type &#x3b1;1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type &#x3b1;1H calcium channels.

Transfected cell line and a method using the same for the high throughput screening for inhibitors of the T-type calcium channel alpha-1H

The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represented by the formula set forth below or its pharmaceutically acceptable salts, and its preparation method thereof. The compound of Formula 1 is a novel piperazinylalkylpyrazole derivative, which particulary has T-type Cachannel blocking effect and thus can be useful as a therapeutic agent for nerve and muscle pain.

Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof

The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein Ris a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C-Calkoxy, a C-Calkyl, and a cyano group; Ris a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C-Calkyl group; and n is 1 or 2.

1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

There is provided a cell line that is prepared by transforming HEK293 cell with a human Kir2.1 gene using a retrovirus expression system, wherein the HEK293 expresses a stable &#x3b1;T-type calcium channel. The cell line responds sensitively to KCl and forms an appropriate level of the membrane voltage so that the cell signaling pathway may be investigated by the molecular biological and biochemical studies.

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The invention is a gene coding for a quinone oxidoreductase fromand a protein having an amino acid sequence expressed therefrom, which can be advantageously used in a reduction reaction of a quinone compound and synthesis of intermediates for a biologically active compound.

Gene coding for quinone oxidoreductase of kluyveromyces marxianus and protein expressed therefrom

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Seoul, South Korea

Hyewhon Rhim