Korea Research Institute of Bioscience and Biotechnology

Yungjin Pharmaceutical Co., Ltd.

Hyeongkyu Lee

Sei-Ryang Oh

Ok-Kyoung Kwon

Doo-Young Kim

Ji-seok Yoo

Dae-hee Shin

Byung-hwan Ryoo

Yongnam Lee

Jung-hee Kim

Kyung-seop Ahn

Hyuk-hwan Song

Hyuk-Hwan Song

Jung-Hee Kim

Dae-Hee Shin

Ji-Seok Yoo

Kyung-Seop Ahn

Byung-Hwan Ryoo

The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract ofvarthan that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.

[object Object]

A method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract ofvarthan that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.

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Daejeon, South Korea

Hyeongkyu Lee