Dong Wha Pharm. Co., Ltd.

Dong Wha Pharmaceutical Ind. Co., Ltd.

Hyeong Su Sim

Sang Jin Park

Sung Joon Yoon

Sang Wook Lee

Jong Woo Kim

Yong Kyun Park

Hwan Bong Chang

Hee Jeoung Park

Yong Ho Chung

Wang Yong Yang

Jae Jin Han

Dong Hyuk Sin

Je In Yoon

Jae In Yoon

Yong Huh

Anti-viral agents of formula (1) have been identified. Their preparation method is described. These 2,5-pyridinedicarboxylic acid derivatives or their pharmaceutically acceptable salts are useful in countering the proliferation of viruses such as hepatitis B virus and human immunodeficiency virus.

2,5-pyridinedicarboxylic acid derivatives

The present invention relates to novel terephthalamide derivatives and in particular to novel terephthalamide derivatives of the following formula 1, its pharmaceutically acceptable salts as antiviral agents having remarkable inhibitory actions against the proliferation of various viruses including HIV and HBV, and preparing method thereof ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same as defined in the detailed description of the present invention.

Terephthalamide derivatives

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Seoul, South Korea

Hyeong Su Sim