Korea Research Institute of Bioscience and Biotechnology

Yungjin Pharmaceutical Co., Ltd.

Korea Institute of Oriental Medicine

Hyeong Kyu Lee

Kyung Seop Ahn

Sei Ryang Oh

Doo Young Kim

Jung Hee Kim

Ok-Kyoung Kwon

Joong Ku Lee

Ok Kyoung Kwon

Mi Jin Kim

Hyouk Joung

Bo Young Park

Gui Hua Quan

Sang Ku Lee

Hyung Won Ryu

In Sik Shin

Jae Wha Kim

Sang Ho Choi

Sang Woo Lee

Semi Kim

Doo-Young Kim

Byung-hwan Ryoo

Dae-hee Shin

Ji-seok Yoo

Yongnam Lee

Seung Hyung Kim

Hyuk Hwan Song

Soon Ja Choi

Ha Young Jang

SuUi Lee

Kyoung-youl Lee

Hwa-Young Son

Mee-Young Lee

Suui Lee

Byung-Hwan Ryoo

Ji-Seok Yoo

Dae-Hee Shin

Ji Won Park

So Young Kim

Sei-Ryang Oh

Gyoon Hee Han

Ho Bum Kang

Su Ui Lee

Joongku Lee

Jae Sung Song

Byung Sun Min

Hang Jin

Joo Heon Kim

Wan Yi Li

Hyun-Jun Lee

Soo Yong Kim

Jung Joo Hong

Goo Taeg Oh

Gun Cheol Kim

Ji Eun Yuk

Yong Yeon Cho

Hea Young Park

Li Wan Yi

Cheol Jung Lee

Jin Hang

Da Chung Ji

Yoosik Yoon

Byoung Whui Choi

Hye Suk Lee

In-Sik Shin

Giselle Tomayo-Castillo

Katia Rosales-Ovares

Rodrigo Gamez-Lobo

Eun Ah Kim

Guang Hai Shen

Seong Kyu Park

Woo Namkung

Yi Hua Pei

Piseth Khiev

Hui Seong Kim

Jin Hyub Paik

Rifatul Widjhati

Fifit Juniarti

Mee Hyun Lee

San Ku Lee

Gyoon Hee 209-1702 Sinyeongtong Hyundai Apt Han

Gui Hua Natural Medicines Research Center Quan

Kyung-Seop Ahn

The present invention relates to a composition for preventing or treating asthma comprising aJ. Poiss. ex Franch extract or a fraction thereof. TheJ. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, theJ. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.

Pharmaceutical composition for preventing or treating asthma comprisingJ. Poiss. ex Franch extract or fraction thereof

A pharmaceutical composition includes any of an extract of, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-&#x3b1; and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.

Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient,extract, fraction, or active fraction thereof

A composition comprising a purified extract isolated fromvar.containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).

Method of treating chronic obstructive pulmonary disease (CPD) with verproside

The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition. Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.

Composition containing lignan compound as active ingredient for preventing or treating cancer

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The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases or asthma comprising aextract or a fraction thereof as an active ingredient, and a health functional food and a feed additive for preventing or improving inflammatory diseases or asthma comprising the extract or the fraction as an active ingredient.

Pharmaceutical composition for preventing or treating inflammatory diseases or asthma, containing lagerstroemia ovalifolia extract or fraction thereof as active ingredient

The present invention relates to an injenane-type diterpene compound derived fromLiou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.

Ingenane-type diterpene compound, and pharmaceutical composition for treating or preventing viral infectious diseases containing same

The present invention relates to a diterpene compound derived from, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.

Phorbol type diterpene compound, pharmaceutical composition for treatment or prevention of viral infectious diseases including same

The present invention relates to a kit for the diagnosis or screening of asthma comprising neuropilin (NRP) gene, and to a method for screening a therapeutic agent for asthma using the same. More precisely, the present invention confirmed that NRP1 expression was increased in asthma patients and byextract. Based on the confirmation, the inventors confirmed that NRP1 could be effectively used as a target for the development of a therapeutic agent for asthma since the suppression of NRP1 expression resulted in the decrease of mRNA, protein, enzyme activity, and promoter activity of MMP-9 in relation to asthma.

Asthma diagnosis using the neuropilin-1 gene, and method for screening for a therapeutic agent for asthma

The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-&#x3b2;1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.

Composition containing styraxlignolide A or the aglycone thereof as an active ingredient for preventing or treating asthma

The present invention relates to a composition comprising an extract ofgenus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract ofgenus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

A pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract ofas an active ingredient. The extract ofof the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-&#x3b1; in macrophages. Therefore, the extract ofof the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-&#x3ba;B, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE, the expression of iNOS and COX-2, and the release of IL-1&#x3b2; and TNF-&#x3b1;, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.

Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity

The present invention relates to a composition comprising an extract ofgenus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract ofgenus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Growing community of inventors

Daejon, South Korea

Hyeong Kyu Lee