Korea Research Institute of Chemical Technology

The Catholic University of Korea Industry-academic Cooperation Foundation

Samsung Life Public Welfare Foundation

Hyeon Young Kim

Chong Ock Lee

Do Hyun Nam

Gildon Choi

Heeyeong Cho

Dae Young Jeong

Woo Kyu Park

Hee-Jong Lim

Ge Hyeong Lee

Ji Hye Choi

Eun Jin Han

Wan Uk Kim

Su Jung Park

Chul Soo Cho

Sae-Bom Yoon

Heung Kyoung Lee

Victor Sukbong Hong

Sunkyung Lee

Ho Jun Seol

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases or tumors, containing, as an active ingredient, a tricyclic compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof, and a health food composition for preventing or alleviating autoimmune diseases or tumors, containing the tricyclic compound as an active ingredient,

Tricyclic compound as IRAK4 inhibitor

The preset invention relates to a novel 8-oxoprotoberberine derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5 containing the same as an active ingredient. The novel 8-oxoproteoberberine derivative or the pharmaceutically acceptable salt thereof according to the present invention can be useful in a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5, particularly rheumatoid arthritis or inflammatory diseases, since it is ascertained that the derivative or a pharmaceutically acceptable salt thereof has remarkably increased oral absorption compared with known protoberberine due to an improvement in the properties thereof, and inhibits the activity of NFAT5 and the secretion of inflammatory cytokines and reduces the expression of NAFT5 in mice with rheumatoid arthritis by directly inhibiting the transcription of NFT5.

8-oxoprotoberberine derivative or pharmaceutically acceptable salt thereof, preparation method therefor and pharmaceutical composition for preventing or treating diseases associated with activity of NFAT5, containing same as active ingredient

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Daejeon, South Korea

Hyeon Young Kim