The Catholic University of Korea Industry-academic Cooperation Foundation

Curogen Technology Co., Ltd.

Bifido Co., Ltd.

Hyeon-Beom Seo

Mi-La Cho

Sung-Hwan Park

Min-Jung Park

Jong-Young Choi

Seung-Ki Kwok

Seon-Yeong Lee

Chang Woo Lee

Joo-Yeon Jhun

Young-Mee Moon

Seung-Hun Lee

Jin-Sil Park

Jin-Kwan Lee

Jae-yoon Ryu

Ji-Won Kim

Dong-Yun Shin

Chul-Woo Yang

Geun Eog Ji

Jun-Geol Ryu

Bin Kwon

Hui Fang

Ji-Hyeon Ju

Jennifer Lee

Keun-Hyung Cho

Se-Young Kim

Yunju Jeong

The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone. Thus, the present invention may be used in the field of pharmaceutics relating to transplantation rejection or various immune disorders possibly occurring after transplantation.

Composition for preventing and treating transplant rejection or transplant rejection diseases, comprising novel compound and calcineurin inhibitor

The present disclosure relates to a method for inhibiting a STAT3 activity comprising administering SSu72 protein.

Method for inhibiting STAT3 activity comprising administering Ssu72

The present disclosure relates to a method of preventing rheumatoid arthritis comprising administering a polynucleotide encoding Ssu72.

Method of preventing rheumatoid arthritis comprising administering polynucleotide encoding SSU72

Provided is a composition containingfor alleviating, preventing or treating rheumatoid arthritis. TheATT newly isolated according to the present invention is useful as a rheumatoid arthritis medicine or a probiotic material for alleviating rheumatoid arthritis owing to potent efficacy in treating rheumatoid arthritis.

Composition containingfor alleviating, preventing or treating rheumatoid arthritis

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Seoul, South Korea

Hyeon-Beom Seo