Chong Kun Dang Corporation

Hyeog Jin Son

Jung Woo Kim

Chung Il Hong

Hyoung Sik Chun

Seung Kee Moon

Hung Bae Chang

Jong Gwan Kim

Nam Hyun Lyu

The present invention relates to Streptomyces sp. producing tautomycetin which possesses an immunosuppressive or antibacterial activities, a process for preparing tautomycetin from the said microorganism, and an immunosuppressant or immunosuppressive pharmaceutical composition comprising tautomycetin as an active ingredient which suppresses interleukin-2 production, CD69 and interleukin-2 receptor(IL-2R) expression on the cell surface, and graft rejection in the organ transplantation. The present inventors isolated a soil microorganism which produces a substance possessing antibiotic and immunosuppressive activities, and identified the said microorganism and substance as a novel Streptomyces sp. and tautomycetin, respectively. Further, the present inventors developed a method of manufacturing the tautomycetin in a large scale from the culture of the said microorganism and discovered that tautomycetin suppresses mouse mixed lymphocyte reaction(MLR) and the expression of IL-2 based on a series of experiments employing cell line transfected with a recombinant gene.

Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient

Growing community of inventors

Seoul, South Korea

Hyeog Jin Son