Baylor Research Institute

Hyemee Joo

Sandra M Zurawski

SangKon Oh

Gerard Zurawski

Yong-Jun Liu

Patrick Blanco

Hideki Ueno

Shino Hanabuchi

Haruyuki Fujita

Sangkon Oh

Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

Methods and compositions for treating autoimmune and inflammatory conditions

Described herein are methods and compositions for treating autoimmunity and inflammatory conditions without non-specific suppression of the host immune system. In particular, the anti-OX40L antibodies described herein are unique in that they not only inhibit the differentiation of inflammatory T cells but also promote the generation and function of regulatory T cells by inducing IL-10 and inhibiting TNF-&#x3b1; and by reducing aberrant Th2 cell responses. Furthermore, the methods and compositions described herein eliminate or reduce aberrant T follicular helper cell&#x2014;(Tfh) responses that may contribute to the pathogenicity of autoimmune disease.

Antagonistic anti-OX40L antibodies and methods of their use

Growing community of inventors

Dallas, TX, United States of America

Hyemee Joo