Leland Stanford Junior University

Hyejun Ra

Christopher H Contag

Gordon S Kino

Butrus Thomas Khuri-Yakub

Olav Solgaard

Michael J Mandella

Jayakumar Rajadas

Omer Oralkan

Jae Eun Hwang

Jae-Woong Jeong

Paul Cristman

Jonathan T C Liu

Emilio Gonzalez

Irfan Ali-Khan

Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.

Confocal microscope, system and method therefor

Encompassed are pharmaceutically acceptable compositions formulated for the topical or transdermal delivery of probes specific for cyclooxygenase-2 (COX-2) of human and non-human subjects. In particular, an activatable probe comprises a fluorescent moiety comprising a fluorophore attached to a compound having selective affinity for COX-2, and a removable fluorescence quencher linked to the fluorescent moiety by a cleavable linker. Upon delivery to a recipient subject, the activatable probe is localized and concentrated in tissues and cells with elevated levels of COX-2. The linker is cleaved to release the fluorescence quencher. Irradiation by an activating incident illumination results in a detectable fluorescent emission signal

Self-quenching activatable COX-2-specific multi-modal molecular probes for diagnosis of cancers, inflammation, and immune system disorders

Growing community of inventors

Sunnyvale, CA, United States of America

Hyejun Ra