Celltrion Inc.

Hye Young Kang

So Young Kim

Su Jung Kim

Joon Won Lee

Jun Seok Oh

Won Yong Han

Yeon Kyeong Shin

Kwang Woo Kim

Jae Bin Lee

Ji Won Roh

Ji Min Kwak

Disclosed is a stable liquid formulation, comprising an antibody or antigen-binding portion thereof, an acetate buffer, glycine, and a surfactant, wherein the stable liquid formulation does not comprise at least one of sugar, a sugar alcohol and a metal salt, and the stable liquid formulation is still stable even upon high antibody content, and is superior in osmolality and viscosity, and subcutaneous administration thereof is possible.

Stable liquid formula comprising anti-TNFa antibody, acetate buffer, and glycine

A stable liquid pharmaceutical formulation according to the present invention includes an antibody or antigen-binding fragment thereof, a surfactant, a sugar or a sugar derivative, a buffer, and a stabilizer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity not only when antibody content is low but also when antibody content is high, and exhibits superior long-term storage stability based on superior stability observed under accelerated conditions and harsh conditions.

Stable liquid pharmaceutical preparation

Stable liquid formula having an anti-TNFalpha antibody, acetate buffer and glycine

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Incheon, South Korea

Hye Young Kang