Korea Institute of Science and Technology

Seoul National University

Hye-Sun Kim

Ick Chan Kwon

Ju Hee Ryu

Young-Ji Ko

Nam-Hyuk Cho

Eun-Jeong Yang

Jae Won Lee

A probe for measuring the activity of caspase-1 according to the present disclosure can specifically image cells or tissues where inflammatory response is induced because it is cleaved by reacting specifically with the active caspase-1 enzyme in vivo and in vitro and re-emits fluorescence. The probe for measuring the activity of caspase-1 can be used for various purposes, such as for imaging of cells or tissues where inflammatory response is induced, as a drug carrier, for screening of a drug inhibiting inflammatory response, etc. The probe for measuring the activity of caspase-1 is applicable both in vivo and in vitro, and can be used for various applications such as high-throughput screening for new drug development, early diagnosis of diseases, etc.

Probe for measuring activity of Caspase-1 and composition for diagnosis of inflammatory diseases containing same

Growing community of inventors

Seoul, South Korea

Hye-Sun Kim