Korea Research Institute of Bioscience and Biotechnology

Hye-Ran Park

Kyeong Seok Lee

Young Kook Kim

Chul-Ho Lee

Jung Joon Lee

Mun-Chual Rho

Hyun Sun Lee

Yongseok Choi

Jeong Hyung Lee

Young Soo Hong

Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient

Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient

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Kyeonggi-do, South Korea

Hye-Ran Park