Seasun Therapeutics

Hye Joo Kim

Hee Kyung Park

Ji-Yeon Yu

Yusun Kang

Deokhwe Hur

Goonho Jeo

Chinbayar Batochir

Dong In Lee

A skin-penetrating carrier containing a nucleic acid complex having a novel structure which introduces a bioactive nucleic acid into cells. Composition for diagnosing, preventing or treating disease and to a skin-penetrating carrier containing a nucleic acid complex in which a bioactive nucleic acid and a carrier peptide nucleic acid are complementarily bound to each other, and having skin permeability and skin retention ability. Skin-penetrating carrier containing nucleic acid complex having structure of Structural Formula (1) has both a skin penetration function of effectively delivering a large-molecular-weight drug and in vivo effectiveness. Carrier enables bioactive nucleic acids or various compounds to pass through the epidermis and dermis of the skin, thus enables external treatment by application to the skin surface.

Skin-permeating carrier containing nucleic acid complex and use thereof

The present invention relates to a nucleic acid complex having a novel structure, which can introduce a bioactive nucleic acid into cells, a composition for treating and diagnosing disease, which comprises the same, and a method of regulating expression of a target gene using the same, and more particularly to a nucleic acid complex comprising a bioactive nucleic acid complementarily bound to a carrier peptide nucleic acid modified to be generally positively charged, a composition for treating and diagnosing disease, which comprises the same, and a method of regulating expression of a target gene using the same.

Peptide nucleic acid complex having improved cell permeability and pharmaceutical composition comprising same

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Daejeon, South Korea

Hye Joo Kim