Korea Research Institute of Bioscience and Biotechnology

Daegu Gyeongbuk Institute of Science and Technology

Daegu-Gyeongbuk Medical Innovation Foundation

Hyang-Sook Hoe

Sang Bum Kim

Hwan Geun Choi

So Young Kim

Jung Beom Son

Nam Doo Kim

Yi Kyung Ko

Seungyeon Lee

Seock Yong Kang

Sun-Hwa Lee

Eunhwa Ko

Jin-Hee Park

Hee Yoon Ryu

Sun Joo Lee

Dayea Kim

Sungchan Cho

Joong-heui Cho

Kyu-Sun Lee

Miri Choi

Ja Wook Koo

Kweon Yu

Joong-Heui Cho

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases

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Daegu, South Korea

Hyang-Sook Hoe