Academia Sinica

Taipei Medical University

Industrial Technology Research Institute

National Health Research Institutes

Hwei-Jiung Wang

An-Suei Yang

Chung-Ming Yu

Hong-Sen Chen

Yi-Kai Chiu

Yueh-Liang Tsou

Cheng-Chung Lee

Chao-Ping Tung

Hung-Ju Hsu

Wei-Chung Yang

Wei-Ying Kuo

Chuan Shih

Chih-Hao Chen

Shih-Hsien Chuang

Chiung-Tong Chen

Yu-Ju Lin

Ing-Chien Chen

Michael Hsiao

Kai-Fa Huang

Hung-Pin Peng

Yi-Jen Huang

Hsin-Ju Hsieh

Shin-Chen Hou

Yu-Chi Chou

Jhih-Wei Jian

Chao-Pin Lee

Chwan-Deng Hsiao

Ya-Wen Chen

Ing-Chein Chen

Shui-Tsung Chen

Ken-Fen Lu

Ming-Chi Peng

Chii-Ruey Tzeng

Chia-Lung Lin

Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.

Method for high-throughput screening of neutralizing antibodies, neutralizing antibodies produced therefrom, and uses thereof

Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.

High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening

Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound. 

Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease

Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.

Immunoconjugate and uses thereof

Described herein are genetically-modified microorganisms for producing medium chain lauric acid and/or dodecanedioic acid and methods of using the microorganisms. The microorganisms contain a nucleic acid encoding anlauroyl ACP-thioesterase (BTE) operably linked to a promoter.

Genetically modified microorganism for producing medium-chain lauric acid and/or dodecanedioic acid and method of using thereof

Provided herein are monoclonal antibodies with a high binding affinity to isoforms of alpha 1-antitrypsin (A1AT), hybridoma cells producing the same, and their uses in diagnosing and/or detecting endometriosis from a serum sample of a subject suspicious of having endometriosis or a subject under health examination.

Specific A1AT monoclonal antibodies for detection of endometriosis

The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and change of the biochemical marker, in particular molecules related to alpha 1-antitrypsin, and comparing with a predetermined baseline level of the biochemical marker contained in serum. Statistical analysis can be performed to evaluate the baseline level indicating the occurrence of endometriosis. Therefore, the present invention can provide an auxiliary guideline for the diagnosis of endometriosis. The present invention also relates to usage of the biochemical marker.

Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers

Growing community of inventors

Taipei, Taiwan

Hwei-Jiung Wang