Tsinghua University

Hwan-You Chang

Chung-Cheng Chou

Cheng-Hsien Liu

Long Hsu

Huang-Ming Philip Chen

Jen-Tsan Ashley Chi

Sung-Yang Wei

Chang-Hung Hsieh

Mao-Chih Hsieh

Yun-Ting Yao

Hung-Yu Yeh

Wei-Chia Chang

Bing-Ying Ho

Te-Yu Chao

Ting-Chou Wei

Yu-Ting Tai

Yuh-Cherng Lai

Yu-Ching Tung

A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array and observation module and a drug mixing module. The cell culture array and observation module are used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array and observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array and observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.

Drug screening platform simulating hyperthermic intraperitoneal chemotherapy

A portable ring-type fluorescence optical system for observing microfluidic channel and an operating method thereof are disclosed. The portable ring-type fluorescence optical system includes a photographic chip, a first polarizer, an objective lens, a ring-type fluorescent light source, a biological sample on a microfluidic chip, a second polarizer and a bottom illumination light source arranged in order from top to bottom. The ring-type fluorescent light source is used to generate a ring-type fluorescent light to the biological sample on the microfluidic chip. The objective lens is used to magnify a fluorescent image of the biological sample on the microfluidic chip to focus on the photographic chip. The first polarizer disposed under the photographic chip and the second polarizer disposed under the biological sample form a non-zero angle to each other to block reflected lights that the biological sample reflects the lights emitted by the bottom illumination light source.

Portable ring-type fluorescence optical system for observing microfluidic channel and operating method thereof

Growing community of inventors

Hsinchu, Taiwan

Hwan-You Chang