Korea Institute of Science and Technology

Hyundai Motor Company

Voronoi Inc.

Kia Corporation

Sqand Co. Ltd.

Voronoibio Inc.

Korea Research Institute of Chemical Technology

Hanmi Science Co., Ltd.

Catholic University Industry Academic Cooperation Foundation

Hwan Oh Kim

Dong-wook Kim

Hwan Geun Choi

Young Jin Ham

Kyung Ho Yoo

Jieun Choi

Jae Chul Lee

Chang Hyun Oh

Eun Jin Jun

Joon-Young Park

Eun Young Kim

Tae Bo Sim

Kwangho Lee

Ji Yeon Song

Young Gil Ahn

Jung Beom Son

Maeng Sup Kim

Nam Doo Kim

Jae Yul Choi

Jung Mi Hah

Gildon Choi

Seung Hyun Jung

Yi Kyung Ko

Yang-Hann Kim

Chong Hak Chae

Young Hee Jung

Byoung Chul Cho

Youn Ho Lee

Eun Hwa Ko

Chae Won Park

Namdoo Kim

Ju Hee Kang

Se In Kang

Jung-Hun Lee

Dong-sik Park

Jung Hun Lee

Hee Sun Ryu

Myoung Eun Jung

Jong-Hwa Lee

Daekwon Kim

Jungbeom Son

Jae Cheol Jeon

Hyunkyung Kim

Jungyeon Yun

Myungho Jung

Sohyun Chung

Heesun Ryu

Hyeonho Jeon

Seo Hyun Jo

Sun Hwa Lee

Ji Yoon Seok

Dahoon Ma

Hua Li

Inji Shin

Wan-Jung Kim

Hyeon Jeong Choe

Byeong Uk Jeon

Krishna Babu Duggirala

Wha Il Choi

Dong Keun Hwang

Da Eun Kim

Min Seok Ryu

Ah Reum Han

The present invention relates to an N-containing heteroaryl derivative and a pharmaceutical composition comprising same as an active ingredient for the prevention or treatment of cancer. The derivative exhibits high inhibitory activity against various protein kinases, particularly excellent ret proto-oncogene (RET) enzyme inhibitory ability, and has an excellent effect of inhibiting the proliferation of medullary thyroid cancer cells and lung cancer cells, which express RET fusion genes, and thus the derivative can be effectively used in the treatment of cancer, for example, medullary thyroid cancer or lung cancer, and particularly, can be effectively used in the treatment of cancer in which RET fusion genes are expressed.

N-containing heteroaryl derivative and pharmaceutical composition comprising same as active ingredient for prevention or treatment of cancer

[Summary] The present invention relates to a pyrrolopyridine derivative and a pharmaceutical composition comprising the same as an active ingredient for prevention or treatment of a protein kinase-related disease. The pyrrolopyridine derivative has excellent inhibitory activity against various protein kinases including LRRK2, DYRK1, and CLK1 and exhibits an excellent suppressive effect on the growth of triple-negative breast cancer cells. A pharmaceutical composition comprising the same as an active ingredient can be advantageously used for treating or preventing protein kinase-related diseases, inter alia, cancers, degenerative brain diseases, and inflammatory diseases, and specifically for treating triple-negative breast cancer.

Pyrrolopyridine derivative and use thereof in prevention and treatment of protein kinase-related disease

Disclosed herein is a black paint composition with improved blackness by controlling a black paint and an additive.

Black paint composition

A vehicle audio video navigation (AVN) system may be provided that includes: a plurality of source providers which receives a sound source; a user operation unit which selects at least one of a plurality of the sound sources input from the plurality of the source providers and selects a focusing zone of the sound source; a processor which generates a sound source signal for focusing an output of the selected sound source on the focusing zone; and a multi-channel amplifier which outputs the sound source signal. As a result, the focusing zone of each sound output within a vehicle can be individually controlled. Particularly, the focusing zone of each sound can be easily selected and controlled without changing the location of the speaker within the vehicle. Also, the sound source and the focusing zone within the vehicle can be selected and controlled only by adding an external processor without replacing the AVN device provided in the vehicle.

Method for controlling sound inside vehicle and vehicle AVN system

Disclosed is a powder paint composition of and a method for preparing the same. More particularly, the present invention relates to a powder paint composition including a powder paint prepared by physically attaching metallic particles to a powder resin, which exhibits no separation or aggregation of metallic particles when coated and significantly improves metallic texture owing to orientation of the metallic particles, and a method for preparing the same.

Powder paint composition and method for preparing same

Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

1,6-disubstituted indole compounds as protein kinase inhibitors

Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors

Disclosed are a 1,3,6-substituted indole compound having inhibitory activity for protein kinases, a pharmaceutically acceptable thereof, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth including the compound as an active ingredient. Since the novel indole compound exhibits superior inhibitory activity for various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

1,3,6-substituted indole derivatives having inhibitory activity for protein kinase

Growing community of inventors

Gyeonggi-do, South Korea

Hwan Oh Kim