Korea Research Institute of Bioscience and Biotechnology

Dongguk University Industry-academic Cooperation Foundation

Neopharm Co., Ltd.

Song Ho Biomed Co., Ltd.

Hwan-Mook Kim

Ki-ho Lee

Song-Kyu Park

Chang-Woo Lee

Kyeong Seok Lee

Kyung-Sook Chung

Mi-Sun Won

Bo-Kyung Kim

Hyun-Seung Ban

Naik Ravi

Sang-Bae Han

Jong-Soon Kang

Jong-Ho Lee

Yong Seok Choi

Byeong-Deog Park

Gyoon-Hee Han

Ki-Hoon Lee

Jong-Kyung Youm

Hyung-Sub Gwak

Mi-Jung Kwon

The present invention relates to novel compounds as HIF-1&#x3b1; inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1&#x3b1;, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1&#x3b1;-mediated VEGFA expression.

Compounds as HIF-1&#x3b1; inhibitors and manufacturing process thereof

Compounds as HIF-1alphainhibitors and manufacturing process thereof

There is provided a composition for preventing and treating obesity including high water-soluble &#x3b2;-cyclodextrin derivatives as an effective component. Specifically, the composition including the high water-soluble &#x3b2;-cyclodextrin derivatives, especially, 2-hydroxypropyl-&#x3b2;-cyclodextrin (HP-&#x3b2;-CD, HPBCD) has effects on suppressing an increase in body weight induced by a high fat diet, suppressing appetite through decreasing an amount of dietary intake, decreasing body fat, decreasing liver weight, and significantly decreasing a sharp increase of blood sugar induced by intaking glucose and maltose on an empty stomach so that it can be useful for preventing and treating obesity, preventing and treating various diseases induced by obesity, and suppressing a sharp increase of blood sugar after dinner.

Composition for treating and preventing obesity including high water-soluble 2-hydroxypropyl-betacyclodextrin as effective component

Disclosed are ceramide derivatives represented by the following formula 1 or 2, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis including the ceramide derivatives as active ingredients: 

Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives

Growing community of inventors

Daejeon, South Korea

Hwan-Mook Kim