The University of Chicago

Hwan Keun Kim

Olaf Schneewind

Dominique Missiakas

Alice G Cheng

Carla Emolo

Andrea Dedent

Dominique M Missiakas

Hye-Young Kim

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant.

Compositions and methods related to protein A (SpA) variants

Compositions and methods related to Protein A (SpA) Variants

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).

Compositions and methods related to antibodies to Staphylococcal protein A

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.

Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response

Disclosed are methods and compositions for treating or preventing abacterial infection using a non-toxigenic Protein A (SpA) variant.

Compositions and methods related to antibodies to staphylococcal protein A

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. In some embodiments, the methods and compositions involve SdrD, ClfA, and/or FnbpB polypeptides.

Methods and compositions involving protective staphylococcal antigens

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by abacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve an Ebh antigen.

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Chicago, IL, United States of America

Hwan Keun Kim