Interleukin Genetics, Inc.

Orig3n, Inc.

Hwa-Ying Wang

Kenneth S Kornman

Steven B Abramson

Nazneen Aziz

John Rogus

Mukundan Attur

Jack F Bukowski

Xiaodong Wu

Kenneth Huttner

An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

Method for determining severity and progression of periodontal disease

Growing community of inventors

Palo Alto, CA, United States of America

Hwa-Ying Wang