Alphora Research Inc.

Sandoz Ag

Huzaifa Rangwala

Boris Gorin

Fabio E S Souza

Ming Pan

Ricardo Orprecio

Jason A Bexrud

Alena Rudolph

Teng Ko Ngooi

Fabio Es Souza

Fabio ES Souza

Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed. 

Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein

The specification relates to compounds and process for the preparation of a compound of formula 7, where LG is a leaving group and hal is a halide and is Cl, Br or I. The compound of formula 7 can be useful in the preparation of natural products, such as halichondrin and its derivatives.

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Mississauga, Canada

Huzaifa Rangwala