Valorisation-recherche, Limited Partnership

Valorisation Hsj, Limited Partnership

Universitéde Montreal

Rsem, Limited Partnership

Valorisation-recherche, Societe En Commandite

Valorisation Hsj, Societe En Commandite

Huy Ong

Sylvain Chemtob

William A Lubell

Caroline Proulx

Florian Sennlaub

Damien Boeglin

Zohreh Sajjadi

David Sabatino

Sylvie Marleau

Ragnhild Gaard Ohm

Yesica Garcia-Ramos

Ahsanullah

Ramesh Chingle

Ngoc-Duc Doan

Dilan Mukandila Mulumba

Kim Beauregard

Samy Omri

André Tremblay

William D Lubell

Robert Hopewell

Jinqiang Zhang

Novel cyclic peptide GHRP-6 analogs of formula (I): (I) or pharmaceutically acceptable esters or salts thereof, are described. These cyclic peptide GHRP-6 analogs may be used for modulating CD36 activity, for example for the treatment of CD36-related diseases, disorders or conditions in a subject, such as atherosclerosis and age-related macular degeneration.

Cyclic peptides and uses thereof

An azapeptide compound of Formula I:A-(Xaa)-N(R)&#x2014;N(R)&#x2014;C(O)-(Xaa')-B &#x2003;&#x2003;I.

Azapeptides as CD36 binding compounds

An azapeptide compound of Formula I:A-(Xaa)-N(R)&#x2014;N(R)&#x2014;C(O)-(Xaa')-B&#x2003;&#x2003;I.

Novel peptidomimetics comprising N-amino cyclic urea residues are disclosed. Use of such peptidomimetics for modulating the activity of CD36 or IL-1 receptor in a cell, and for treating CD36- or IL-1-related disease, disorder or condition is also described.

Peptidomimetics comprising N-amino cyclic urea residues and uses thereof

An azapeptide derivative of growth hormone releasing peptide (GHRP) of Formula I: A-(Xaa)-N(R)&#x2014;N(R)&#x2014;C(O)-(Xaa')-B which binds to CD 36.

According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method comprises administration of one or more Growth Hormone Releasing Peptides (GHRPs) to a patient in need of such treatment or prophylaxis. There are also provided methods of reducing blood plasma cholesterol levels, as well as methods of modulating the expression of the scavenger receptor CD36 and genes involved in cellular cholesterol efflux.

Growth hormone-releasing peptides in the treatment or prevention of atherosclerosis and hypercholesterolemia

Growing community of inventors

Ville Mont-Royal, Canada

Huy Ong