University of Saskatchewan

Ciba-Geigy Canada Ltd.

Veterinary Infectious Disease Organization

Huw P Hughes

Andrew A Potter

Manuel Campos

Mark J Redmond

New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

Vaccines with chimeric protein comprising gamma-interferon and

New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.

Enhanced immunogenicity using leukotoxin chimeras

Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or

New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

Gamma-iterferon-leukotoxin gene fusions and uses thereof

Interleukin-2-leukotoxin gene fusions and uses thereof

Growing community of inventors

Saskatoon, Canada

Huw P Hughes