Incyte San Diego Inc.

Ortho-mcneil Pharmaceutical Corp.

Arena Pharmaceuticals, Inc.

Maxia Pharmaceuticals, Inc.

Hussien A Al-Shamma

Catherine Tachdjian

Magnus Pfahl

Lyle W Spruce

Andrea Fanjul

Robert M Jones

James N Leonard

Zhi-Liang Chu

David P M Pleynet

Torsten R Wiemann

James Zapf

Jianhua Guo

Karine Jakubowicz-Jaillardon

Mohamed Boudjelal

Andrea Fanjul Giachino

Richard Masten Fine

Jason B Ibarra

David Pm Pleynet

The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level

Methods for identifying GLP-1 secretagogues

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease 

Substituted heterocycles for the treatment of diabetes and other diseases

The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis. 

Bicyclic heterocycles for the treatment of diabetes and other diseases

The invention relates to certain heterocyclic compounds useful for the treatment of cancer and other diseases, having the Formula (I): wherein:

Heterocyclic derivatives for the treatment of cancer and other proliferative diseases

The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Arform a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.

Heterocyclic amide derivatives for the treatment of diabetes and other diseases

The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia: 

N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

Imidazolidinedione derivatives for the treatment of diabetes and other diseases

Thiazolidinedione derivatives for the treatment of diabetes and other diseases

Heterocyclic derivatives for the treatment of diabetes and other diseases

Growing community of inventors

Encinitas, CA, United States of America

Hussien A Al-Shamma