The Ohio State University

Wisconsin Alumni Research Foundation

Hussein M Abou-Issa

Margaret Clagett-Dame

Robert W Curley, Jr

Thomas E Webb

John P Minton

Galal A Alshafie

Joel R Walker

Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.

C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and methods of using the same to inhibit neoplastic cell growth

C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and method of using the same to inhibit neoplastic cell growth

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The present invention describes a protocol for achieving a very high degree of anticarcinogenic (or chemopreventive or cancer preventative) activity through the combination of a low suboptimal dose of a D-glucarolactone-based dietary anticarcinogen (i.e., calcium glucarate or CGT) with a low suboptimal dose of retinoid-based anticarcinogen (4-hydroxyphenyl retinamide or HPR). Since synergism is obtained by this combination, these two anticarcinogens can be employed at dosages far below toxic levels and at dosages that are practical as a food supplement.

Method and composition for achieving anticarcinogenic activity

The present invention describes a dietary supplement for achieving a very high degree of chemotherapeutic activity through the synergistic combination of a low suboptimal dose of a D-glucarolactone-based dietary anticarcinogen (calcium glucarate) with a low suboptimal dose of retinoid-based anticarcinogen (4-hydroxyphenyl retinamide).

Method and composition for achieving chemotherapeutic activity

The present invention describes a protocol for achieving a very high degree of anticarcinogenic (chemopreventive and chemotherapeutic) activity through the combination of low suboptimal doses of a D-glucarolactone-based dietary anticarcinogen with low suboptimal doses of a retinoid-based anticarcinogen. Synergism is obtained by this combination and these two anticarcinogens can be employed at dosages far below toxic levels and at dosages that are practical as a food supplement.

Growing community of inventors

Columbus, OH, United States of America

Hussein M Abou-Issa