Natera, Inc.

Ucl Business Plc

Huseyin Eser Kirkizlar

Bernhard Zimmermann

Styrmir Sigurjonsson

Tudor Pompiliu Constantin

Matthew Rabinowitz

George Gemelos

Matthew Micah Hill

Onur Sakarya

Joshua Babiarz

Lane A Eubank

Allison Ryan

Raheleh Salari

Naresh Vankayalapati

Zachary Demko

Milena Banjevic

Johan Baner

Ryan Swenerton

Robert Charles Swanton

Christopher Abbosh

Bernhard Zimmerman

Solomon Moshkevich

Felipe Acosta Archila

Tudor Popiliu Constantin

Mariam Jamal-hanjani

Gareth Wilson

Mariam Jamal-Hanjani

The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.

Detecting mutations and ploidy in chromosomal segments

The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

Methods for detection of donor-derived cell-free DNA

The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.

Methods for simultaneous amplification of target loci

The invention provides methods for detecting single nucleotide variants in lung cancer, especially stage 3a lung adenocarcinoma and lung squamous cell carcinoma. Additional methods and compositions, such as reaction mixtures and solid supports comprising clonal populations of nucleic acids, are provided.

Methods for lung cancer detection

The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.

Methods and compositions for determining ploidy

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Los Angeles, CA, United States of America

Huseyin Eser Kirkizlar