Hi LLC

Husam Katnani

Ryan Field

Bruno Do Valle

Jacob Dahle

Rong Jin

Bryan Johnson

Isai Olvera

Antonio H Lara

Katherine Perdue

Daniel Sobek

Alejandro Ojeda

Jamu Alford

Gabriel Lerner

Ethan Pratt

Sebastian Sorgenfrei

Scott Jeremy Seidman

Julian Kates-Harbeck

Zachary Phillip Sheldon

Alan Millman

Viktoria Rojkova

Julien Dubois

An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user; and a module configured to be removably inserted into the wearable assembly and comprising: a housing, a printed circuit board (PCB) and a light guide assembly configured to emit light directed at a target within the user. The light guide assembly comprises: a lower light guide portion housed within the housing and having a proximal end attached to the PCB, a conductive spring member housed within the housing and comprising a coil positioned around an external surface of the lower light guide portion, and a conductive upper light guide portion connected to the lower light guide portion and configured to protrude from an upper surface of the housing and be in contact with a surface of a body of the user.

Multimodal wearable measurement systems and methods

An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit configured to measure a noise level of a photodetector included in the array of photodetectors, the noise level comprising a dark count rate that measures a dark count divided by a time period, determine that the noise level meets a predetermined threshold comprising a dark count rate threshold, and prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors, the preventing comprising switching the output to a monitoring circuit that monitors a characteristic of the optical measurement system separate from the photodetector.

Photodetector calibration of an optical measurement system

A non-invasive product customization system and a method of customizing a product formulation is provided. Brain activity of a user is detected in response to an input of a product formulation into a brain of the user via a sensory nervous system of the user. A mental state of the user is detected based on the detected brain activity. The product formulation is modified based on the determined mental state of the user. The modified product formulation may be presented to the user in a manner that modulates the mental state of the user.

Non-invasive system and method for product formulation assessment based on product-elicited brain state measurements

A wearable module for use in an optical measurement system includes a light guide configured to receive a light pulse from a light source and guide signal photons included in the light pulse toward a target within a body of a user, and a light diverter configured to divert reference photons included in the light pulse toward at least one detector configured to detect the reference photons.

Time domain-based optical measurement systems and methods configured to measure absolute properties of tissue

A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Biofeedback for awareness and modulation of mental state using a non-invasive brain interface system and method

An illustrative optical measurement system includes a light source configured to emit light directed at a target, an array of photodetectors configured to detect photons of the light after the light is scattered by the target, and a processing unit. The processing unit is configured to measure a noise level of a photodetector included in the array of photodetectors and determine that the noise level meets a predetermined threshold. The processing unit is further configured to prevent, based on the determining that the noise level meets the predetermined threshold, an output of the photodetector from being used in generating a histogram based on a temporal distribution of photons detected by the array of photodetectors.

An illustrative multimodal measurement system includes a wearable assembly configured to be worn by a user and comprising a plurality of light sources each configured to emit light directed at a target within the user, a plurality of detectors configured to detect arrival times for photons of the light after the light is scattered by the target, and a plurality of electrodes configured to be external to the user and detect electrical activity of the target.

A wearable module assembly for an optical measurement system includes a first wearable module, a second wearable module, and a connector. The first and second wearable modules each include a light source configured to emit a light pulse toward a target within a body of a user, a housing that houses the light source and the plurality of detectors and includes a substantially hexagonal surface that faces a surface of the body of the user when the wearable module assembly is worn by the user, and a plurality of detectors each positioned at a fixed distance from the first light source and each configured to detect a set of photons included in the light pulse after the set of photons are scattered by the target. The connector directly connects the first wearable module and the second wearable module at mutually-facing side surfaces of the respective housings.

Wearable module assemblies for an optical measurement system

A physiological activity detection system comprises a signal acquisition module configured for non-invasively acquiring a signal from an anatomical structure of a user, the acquired signal having a physiological-encoded component and a periodic artifact component that dominates the physiological-encoded component. The physiological activity detection system further comprises a phase-locked loop (PLL) component configured for estimating a phase of the periodic artifact component of the acquired signal, and generating a periodic reference signal having a phase representative of the estimated phase of the periodic artifact component of the acquired signal.

Real-time periodic artifact extraction from a physiological signal

A non-invasive system and method are provided. Brain activity of a user is detected using a non-invasive brain interface when the user is exposed to an external stimulus. The user is determined to be negatively primed by the external stimulus based on the detected brain activity. An alert that the user is being negatively primed by the external stimulus is automatically provided. A tagged training session may be automatically provided to the user in response determining that the user has a negative mental state, thereby promoting a positive mental state of the user. A training session list containing the tagged training session may be automatically modified based on the determined mental state of the user.

Non-invasive systems and methods for the detection and modulation of a user's mental state through awareness of priming effects

An illustrative optical measurement system may include a wearable assembly comprising a plurality of modules each configured to fit within a different slot of the wearable assembly. The plurality of modules may include a module that comprises first and second light sources each configured to emit light directed at a target and a set of detectors configured to detect arrival times for photons of the light emitted by the first and second light sources. A ratio of a total number of the detectors to a total number of the light sources is at least two to one.

High density optical measurement systems with minimal number of light sources

A mental impairment detection system and non-invasive method of detecting mental impairment of a user are provided. A test (e.g., an inhibitory reflex test or a sustained attention test) is administered to the user, brain activity in a frontal lobe of the user is non-invasively detected while the test is administered to the user, and a level of mental impairment of the user is determined based on the brain activity detected in the frontal lobe of the user.

Non-invasive systems and methods for detecting mental impairment

A system for training a neurome that emulates a brain of a user comprises a non-invasive brain interface assembly configured for detecting neural activity of the user in response to analog instances of a plurality of stimuli peripherally input into the brain of the user from at least one source of content, memory configured for storing a neurome configured for outputting a plurality of determined brain states of an avatar in response to inputs of the digital instances of the plurality of stimuli, and a neurome training processor configured for determining a plurality of brain states of the user based on the detected neural activity of the user, and modifying the neurome based on the plurality of determined brain states of the user and the plurality of determined brain states of the avatar.

Methods for training and using a neurome that emulates the brain of a user

An illustrative research support computing system maintains subject data representative of attributes for research subjects included in a potential subject pool for potential research studies. The system receives, from a client device, an input dataset representative of: 1) a set of parameters defining a research study to be conducted with respect to a research subject group, and 2) a set of criteria for research subjects that are to be included in the research subject group. The system designates a research subject included in the potential subject pool for inclusion in the research subject group based on the set of criteria, and receives research data detected for the research subject in accordance with the set of parameters. The system also provides an output dataset generated based on the research data detected for the research subject in accordance with the set of parameters. Corresponding methods and systems are also disclosed.

Methods and systems for initiating and conducting a customized computer-enabled brain research study

An illustrative wearable brain interface system includes a headgear configured to be worn on a head of a user and a plurality of photodetector units configured to attach to the headgear, the photodetector units each housing a photodetector included in a plurality of photodetectors configured to be controlled by a master control unit to detect photons of light.

Wearable brain interface systems including a headgear and a plurality of photodetector units each housing a photodetector configured to be controlled by a master control unit

Growing community of inventors

Braintree, MA, United States of America

Husam Katnani