Takeda Pharmaceutical Company Limited

Huong-Thu Ton-Nu

John David Lawson

Jeffrey Alan Stafford

Jun Feng

Young K Chen

Zacharia S Cheruvallath

Christopher McBride

Mingnam Tang

Joanne Miura

Erick Wang Co

Sean Timothy Murphy

Mallareddy Komandla

Prasuna Guntupalli

Philip Erickson

Wolfgang Reinhard Ludwig Notz

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, and Rare defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with MetAP2.

Indazole derivatives

The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

HSP90 inhibitors

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San Diego, CA, United States of America

Huong-Thu Ton-Nu