Axxia Technologies

Other

Johns Hopkins University

Wright Medical Technology, Inc.

Hungnan Lo

Kam W Leong

Stuart A Grossman

Glenn J Lesser

Hai-Quan Mao

James Perry English

Zhong Zhao

Wenbin Dang

David Peter Nowotnik

Sudhakar Kadiyala

Cary P Hagan

Kelly Schlachter

James J Chao

Rick P Swaim

This invention is generally directed to methods and materials for connective tissue repair. The invention is more specifically related to methods and materials for the repair of tendons and ligaments, especially in the hand. Methods and materials for rotator cuff repair are also disclosed. The use of extraoperatively obtained scaffolding matrices is promoted when reapproximating the connective tissue.

Methods and materials for connective tissue repair

Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I:

A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.

Subcutaneous implant

Subcutaneous implant for delivery of hydromorphone

A structurally rigid biodegradable foam scaffold useful for cell transplantation is provided. The foam can be loaded with nutrients and/or drugs that elute from the foam during transplant to promote growth of the cells. The foam, which features a continuous network of pores, is fabricated using a novel method involving phase separation and consequent expansion upon sublimation of a liquid solvent, preferably naphthalene.

Biodegradable foams for cell transplantation

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Baltimore, MD, United States of America

Hungnan Lo