Atomic Energy Council-institute of Nuclear Energy Research

Hung-Wen Yu

Wuu-Jyh Lin

Yu Lung Chang

Cheng-Fang Hsu

Mei-Hui Wang

Chih-Yuan Lin

Jen-Tsung Wang

Wei-Ti Kuo

A method for preparing a precursor used to label hepatocyte receptors is revealed. The precursor contains a bifunctional structure including trisaccharide and DTPA ligand. During synthesis processes of the precursor, silica gel columns and Reverse phase-18 (RP-18) columns are used for purification. Thus both the purification times and cost of each purification are reduced. Moreover, use diethyl ether to facilitate precipitation of products and remove a part of coupling reagent. Removing the coupling reagent helps purification of products. Furthermore, N,N-bis(carboxymethyl)-L-lysine hydrate and benzyl chloroformate are coupled to form a trisaccharide skeleton so as to ensure the yield rate of trisaccharide structure.

Method for preparing precursor used for labeling hepatocyte receptor and containing trisaccharide and DTPA ligand

Growing community of inventors

Taoyuan County, Taiwan

Hung-Wen Yu