Tsinghua University

Hung-Lun Chu

Jya-Wei Cheng

Hui-Yuan Yu

Ya-Han Chih

An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) A-L-C, wherein Aand Cindependently is a short peptide with &#x3b1;-helix, L is AGP (Ala-Gly-Pro) or a peptide bond, and the hydrophobicity of the hydrophobic terminus in the anti-endotoxin polypeptide is between about 0.425 and 0.765. The anti-endotoxin polypeptide of the invention can neutralize the lipopolysaccharide and has the low hemolysis and high salt resistance, simultaneously. The present invention also provides a method for design an anti-endotoxin polypeptide, the anti-endotoxic activity is adjusted through increasing and/or decreasing hydrophobicity of the hydrophobic terminal end.

Anti-endotoxin polypeptide

A peptide with antimicrobial, anticancer and/or wound-healing promoting activities is provided. The peptide with antimicrobial, anticancer and/or wound-healing promoting activities, includes: an &#x3b1;-helix peptide; and a short peptide consisting of about 4-10 positively charged amino acids, connected to an N-terminus of the &#x3b1;-helix peptide to form the peptide with antimicrobial, anticancer and/or wound-healing promoting activities, wherein the total length of the peptide with antimicrobial, anticancer and/or wound-healing promoting activities is about 10-20 amino acids.

Peptides with antimicrobial, anticancer and/or wound-healing promoting activities, pharmaceutical compositions containing the same, and use of the peptides with antimicrobial, anticancer and/or wound-healing promoting activities

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Hsinchu, Taiwan

Hung-Lun Chu