Mackay Memorial Hospital

Chung Yuan Christian University

Other

National Taipei University of Technology

Chang Gung University

Mackay Medical Foundation the Presbyterian Church in Taiwan Mackay Memorial Hospital

Goldred Nanobiotech Co., Ltd.

Mackay Medical College

Asclepiumm Taiwan Co., Ltd

Hung-I Yeh

Hsueh-Hsiao Wang

Liang-Chia Chen

Chun-Wei Chen

Chun-wei Chen

Cheng-An J Lin

Pei-Wen Hsieh

Shih-Wei Wang

Min-che Chen

Wei-Chih Hu

Walter H Chang

Chung-Lieh Hung

Yu-Jun Lai

Wai-Lun Zhang

Hong-Shong Chang

Chi-Sheng Lu

Ching-Hu Chung

Cheng-Huang Su

Min-Che Chen

Disclosed herein is a method for treating an inflammatory disease in a subject, including administering to the subject a therapeutically effective amount of a dihydrolipoic acid (DHLA) coated gold nanocluster about 0.1 to 20 nm in diameter. Also disclosed is a method for reducing the expression of a pro-inflammatory molecule in a cultured cell, including contacting the cultured cell with the said DHLA coated gold nanocluster. Still disclosed is a pharmaceutical composition that includes the present DHLA coated gold nanocluster. The pharmaceutical composition is useful for treating the inflammatory disease in the subject.

Method for treating inflammatory diseases

Disclosed herein are methods for treating an angiogenesis-related condition or disease in a subject in need thereof. Said method includes administering to the subject a peptide having at least 90% sequence identity of the sequence of SEQ ID NO: 1 or SEQ ID NO:3 in a therapeutically effective amount.

Use of peptide for treating angiogenesis-related diseases

The invention relates to a use of an aurantiamide dipepetide derivative in the treatment or prevention of angiogenesis-related diseases. Accordingly, aurantiamide dipeptide derivatives can be used as angiogenesis inhibitor, whereby preventing or treating invasive and metastatic cancer and ocular neovascularization (particularly macular degeneration such as pathological neovascularization of age-related macular degeneration (AMD)).

Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases

An evaluation system for determination of cardiovascular function parameters is provided. The evaluation system includes a data reading module, an image generating module, a contour determination module, an active contour module, a geometric center axis computing module, a view angle selection module and a function evaluation module. After reading cardiovascular graphic files with the data reading module, the image generating module displays 2D images or a 3D image constructed from the 2D images. Then, active contours are generated by the contour determination module and the active contour module, so as for the geometric center axis computing module to calculate geometric center axes. The view angle selection module then rotates the 3D image according to the view angle data received and modifies the 2D image files accordingly to generate plural cross-section images of the 3D image. Finally, the function evaluation module calculates evaluation parameters according to the geometric center axes. Thus, evaluation parameters can be derived from cardiovascular ultrasound images for clinical diagnosis in the evaluation of cardiovascular functions.

Evaluation system or determination of cardiovascular function parameters

Disclosed herein is the novel use of a gold nanocluser for ameliorating oxidative stress and/or aging of a cultured cell or a subject having an oxidative stress and/or aging condition mediated by a vascular factor. The gold nanocluster has a particle size ranging from about 0.1 to 20 nm, and preferably is dihydrolipoic acid (DHLA) coated gold nanocluster.

Use of gold nanoclusters in ameliorating oxidate stress and/or aging

The present invention is disclosed an array-type-transducer-based high-power ultrasound delivery system which includes a support bracket, an array-type ultrasound transducer, and a plurality of containers. The support bracket includes a plurality of grooves, and the array-type ultrasound transducer includes a clamp and N ultrasound transducers. The clamp includes a plurality of wedges configured for engaging in the grooves of the support bracket and thereby connecting the array-type ultrasound transducer to the support bracket. The containers are arranged in a two-dimensional matrix so that the ultrasound transducers of the array-type ultrasound transducer can dip into and leave the ultrasound-conducting medium in the containers vertically. The disclosed system features high operation speed and low labor requirement. Moreover, the depth by which and the time for which the ultrasound transducers dip into the ultrasound-conducting medium in the containers can be controlled and quantified.

Array-type-transducer-based high-power ultrasound delivery system

The present invention provides a stroboscopic optical image mapping system comprising a control module, an optical module, and an image acquiring unit. The control unit forms a delayed pulse signal by modulating a first pulse signal having a plurality of pulses with a pulse period, wherein a time interval between two adjacent pulses of the delayed pulse signal has a time difference with respect to the pulse period. The optical module provides an incident light to be projected on an organic object, which has a dye therein and is stimulated by a second pulse signal for generating a sequential action potential. The fluorescence generates from the dye inside the organic object, which corresponds to the intensity of the sequential action potential. The image acquiring unit is actuated to acquire the fluorescent light according to the delayed pulse signal, thereby forming a plurality of fluorescent images.

Stroboscopic optical image mapping system

Growing community of inventors

Taipei, Taiwan

Hung-I Yeh