Massachusetts Institute of Technology

Children's Medical Center Corporation

Hung-Chieh Chou

Robert Samuel Langer

Daniel Griffith Anderson

Arturo Jose Vegas

Yunlong Zhang

Rosemary Lynn Kanasty

Benjamin C Tang

Michael J Webber

Yair Levi

Compounds, compositions, and methods for 'smart' delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

Insulin derivatives for diabetes treatment

Growing community of inventors

Cambridge, MA, United States of America

Hung-Chieh Chou