Korea University Research and Business Foundation

Hun-Ho Jo

Ji-young Kim

Jae-Hong Seo

Chang-Ill Ban

Young-Kwan Cho

Eun-Hye Oh

Chang Ill Ban

This invention relates to a complex for cancer cell chemotherapy and, more particularly, to an AGTR1 aptamer-anticancer drug complex for chemotherapy of cancer cells, which includes a nucleic acid aptamer specifically binding to AGTR1 and an anticancer drug linked with the nucleic acid aptamer, so that AGTR1-positive (overexpressed) breast cancer cells are selectively targeted and killed.

AGTR1 aptamer-anticancer drug complex for cancer cell chemotherapy

A method of manufacturing a complex for cancer cell chemotherapy comprises an aptamer preparation step of preparing a nucleic acid aptamer having an aptamer base sequence specifically binding to HER2, and a complex formation step of forming an aptamer-anticancer drug complex by reacting the aptamer prepared in the aptamer preparation step with an anticancer drug.

HER2 aptamer-anticancer drug complex for cancer cell chemotherapy

This invention relates to a complex for cancer cell chemotherapy and, more particularly, to a HER2 aptamer-anticancer drug complex for chemotherapy of cancer cells, which includes a nucleic acid aptamer specifically binding to HER2 and an anticancer drug linked with the nucleic acid aptamer, so that HER2-positive breast cancer cells are selectively targeted and killed.

Growing community of inventors

Busan, South Korea

Hun-Ho Jo