Edc Biosystems, Inc.

Intuitive Surgical Operations, Inc.

Humphrey W Chow

Michael James Forbush

Charles A Reichel

Tarlochan S Jhutty

Roger O Williams

Michael R Van Tuyl

Marina Nasilevich

James E Sinclair

Amy E Kerdok

John W Zabinski

Andrew M Rose

Gary C Ettinger

Justin Krom

Craig Gotsill

James Chiao

Stefan Geiger

Daryl Oshatz

Russell Blanchard

Sarah Galvis

Kevin Thompson

A sterile drape assembly may comprise a drape and a cable guide coupled or configured to be coupled to the drape. The drape may comprise a first portion configured to cover a medical device holder and a second portion configured to cover a portion of an arm that supports the medical device holder. The cable guide may comprise two opposing guidepost arms extending in a first direction and defining a first opening and a side arm extending laterally from one of the guidepost arms, the side arm defining a second opening. The first opening is configured to receive and route a first transmission line along a first path. The second opening is spaced from the first opening and is configured to receive and route a second transmission line along a second path spaced from the first path.

Devices, systems, and methods for maintaining a sterile surgical field

An apparatus includes a sterile channel pre-drape assembly comprising a plurality of legs radiating from a common center region. Each of the plurality of legs has one or more sterile interior surfaces and one or more outer surfaces. The sterile interior surfaces of a pair of the plurality of legs define a sterile channel that is bounded by the outer surfaces of the pair of the plurality of legs. The sterile channel pre-drape assembly also includes an attachment element affixed to the sterile channel pre-drape assembly. The attachment element is configured to attach the sterile channel pre-drape assembly to a portion of a surgical system.

Sterile channel pre-drape assembly

The present invention comprises a method for calibrating a droplet dispensing apparatus using acoustic energy to dispense a plurality of droplet sets of a liquid from a source container into a plurality of target containers, with each droplet set being comprised of one or more individual droplets of the liquid, and with a liquid level of the liquid in the source container being measured before each of the droplet sets are dispensed. The average droplet volume for the individual droplets in each of the droplet sets is then calculated by detecting the presence of an indicator, such as a fluorescent chemical. Once the average droplet volume has been calculated, it is determined if the average droplet volume for each droplet set is acceptable or not acceptable. Where the average droplet volume is determined to be not acceptable, an existing droplet dispensing parameter is changed to a new droplet dispensing parameter that will cause the average droplet volume for that droplet set to change. A burst curve is then generated that will cause the new droplet dispensing parameter for each droplet set to be used if a subsequent plurality of droplet sets are dispensed.

Method for calibrating an acoustic droplet dispensing apparatus

An apparatus for high-throughput screening and generation of chemical libraries. The apparatus comprises computer controlled mechanical displacement devices and storage queues capable of managing a large number of source well plates and target well plates. In one aspect of the invention, precession alignment mechanisms are provided for efficient transfer of liquid from source well plates to target well plates. The apparatus may be configured such that any source fluid in any of the source well plates may be transferred to any target location within any of the target well plates in any sequence defined by the user. The computer controller may track the location of all the source well plates and target well plates and allow user defined association of any source well with any target well in any order defined by the user, thus providing an effective platform for chemical and biochemical synthesis and screening.

Source and target management system for high throughput transfer of liquids

The present invention comprises a noncontact method for measuring viscosity and/or surface tension information of a liquid in a liquid containment structure. The steps of the method include exciting a surface of the liquid with an excitation burst of acoustic energy that causes the surface to oscillate; generating a positional data set comprised of a plurality of positional measurements related to the detected position of the surface at a plurality of times after the surface is excited; generating a frequency domain data set from the positional data set, the amplitude spectrum of the frequency domain data set comprising information about the oscillation frequency of at least one vibrational mode of the of the surface as it oscillates; and processing the frequency domain data set and/or the positional data set to yield information about the surface tension and/or viscosity of the liquid. A Fast Fourier Transform technique may be used in generating the frequency domain data set.

Acoustic method for determining the viscosity and/or surface tension of a liquid

Devices useful in liquid transfer applications and in particular, devices for controlling the free surface of a source liquid in acoustic liquid ejection systems are disclosed. The devices advantageously maintain a source liquid to be transferred at a constant height and reduce disturbances formed in the liquid due to droplet ejection. In one variation, a well plate includes a plurality of wells each having a capillary. Source liquid in a well moves up the capillary due to capillary action and arrives at a certain height. The height arrived at remains constant despite the source liquid depleting from the well during the ejection process. The capillary can be separately joined or integral with the well plate. An acoustic wave emitter positioned adjacent to the well plate emits a focused acoustic beam that causes at least some of the liquid in the capillary to be ejected.

Apparatus for controlling the free surface of a liquid in a well plate

An apparatus for high-throughput screening and/or generation of chemical libraries. In one aspect of the invention, a database is provided to track various parameters related to the source fluids in the source containment structure. Tracking changes of the source fluids in each source well may allow efficient utilization of source fluid and may also facilitate the high-throughput fluid transfer process. In one variation, data related to fluid level in each source well is maintained such that proper positioning of acoustic wave focus may be achieved. In another aspect of the invention, a database associated with one or more source fluid containment structure is provided and updated during the fluid transfer process. A second database providing a mapping profile with information regarding which fluid is to be transferred to what target is also provided. A third database may be generated to track fluid information in the target well plates.

Acoustically mediated liquid transfer method for generating chemical libraries

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Cupertino, CA, United States of America

Humphrey W Chow