University of Saskatchewan

Humphrey Fonge

Clarence Ronald Geyer

Ayman Elsayed Mohammad

Kris Barreto

Bharathikumar Vellalore Maruthachalam

Siddesh Vrushabendra Swamy Hartimath

Jianghai Liu

The disclosure provides radiolabeled and/or cytotoxin labelled antibodies and methods and uses of these antibodies. In one embodiment, provided is a cytotoxic agent comprising an antibody that specifically binds a target disease cell surface receptor, a cytotoxin, and a radiolabel, wherein the cytotoxin is linked directly or indirectly to the antibody, and wherein the radiolabel comprises a radionuclide and optionally a scaffold, wherein the scaffold is directly or indirectly coupled to the antibody. Also provided are methods of preparing the cytotoxic agent and methods of treating disease using the cytotoxic agent.

Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies

The disclosure is directed to antibodies and binding fragments thereof that specifically bind HER3. The disclosure is further directed to immunoconjugates comprising the antibodies and binding fragments thereof that specifically bind HER3. The disclosure is also directed to uses of the antibodies, binding fragments thereof and immunoconjugates for detecting HER3-expressing cells and for treating HER3-expressing cancer.

HER3 binding agents and uses thereof

Growing community of inventors

Saskatoon, Canada

Humphrey Fonge