Kureha Kagaku Kogyo Kabushiki Kaisha

Humio Tamura

Kiro Asano

Hiromitsu Tanaka

Satoru Enomoto

Tsuyoshi Saito

Hisayuki Wada

Yoshio Kawai

Yoichi Suzuki

Kenji Bannai

Satoshi Mitsuhashi

Tadahiro Matsudaira

Yushi Nezu

Satoru Enomotol

Toichi Suzuki

Disclosed herein are (1) a fluorescent substance represented by the formula (I), (2) a process for producing the fluorescent substance, and (3) a cell-discriminating agent containing the fluorescent substance as an active ingredient. ##STR1## (wherein n is an integer of 0, 1, 2 or 3 and R represents a residual radical of a fluorescent material.)

Chlorambucil derivatives and cell-discriminating agent containing the

Disclosed herein is an injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-bis(2-chloroethyl)amino)phenyl }butanoyloxy]acetate, which has been known as an orally administrable anti-tumor substance, as an active ingredient and an ester of iodinated poppy oil fatty acid as a solvent.

Injection containing

Disclosed herein is an immunoregulator comprising a derivative of estradiol represented by the formula (I), which immunoregulator has a small influence to the non-specific immunoreactions in general and gives a specific influence to the immunoreactions against an isoantibody. ##STR1##

Immunoregulator comprising a derivative of estradiol

A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of ##STR2##

Steroid hormone-antitumor derivatives

The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formula

Chlorambucil derivatives

Methylated prostaglandine derivatives are steroids derivatives having at 17 position, methylated prostaglandine group such as

Methylated prostaglandin derivatives

Solid carbon material having extremely high flexural strength can be produced by introducing a sufficient amount of functional group to satisfy the undernoted general equation into a pitch having a H/C atomic ratio of 0.8 at most, thereby obtaining precursory carbon material; shaping said precursory carbon material into a desired article without using any binding material; and carbonizing or further graphitizing said article; wherein the general equation is ##EQU1## where, H/C is the hydrogen-to-carbon atomic ratio of the pitch, R is a numeral ranging from 0.2 to 0.3, and f is the percent by weight of at least one of oxygen, sulfur and halogen contained in the total functional groups introduced into the precursory carbon material on the basis of the weight thereof.

Method for producing solid carbon material having high flexural strength

Process for the preparation of Chlorambucil derivatives

A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.4 alkylene group and X represents a halogen atom, amino group, hydroxyl group, carboxyl group or a salt thereof, with a modified or non-modified reactive group of an antitumor drug to form a binded group of --O--, --COO--, --CONH--, --NH-- or ##STR2##

Prostaglandine derivatives are composed of a prostaglandine and a steriod hormone with or without a binding group. The prostaglandine derivatives have extraordinarily reduced side-effect and superior physiological activity, particularly effect of abortion in comparison with those of prostaglandines.

Prostaglandine derivatives

Crystalloidal pitch is obtained by subjecting solid pitch particles measuring not more than 5 mm in cross-sectional equivalent diameter to a treatment to prevent cohesion and subsequently bringing the cohesion-proof solid pitch particles into contact with a non-oxidative gas at temperatures of from 350.degree. C to 550.degree. C while maintaining a gas flow rate sufficient to provide a suspension wherein the gas constitutes at least 30% by volume. The crystalloid pitch is useful as a precursor for various carbon products.

Growing community of inventors

Kukizaki, Japan

Humio Tamura