Nippon Paper Industries Co., Ltd.

Sanwa Kagaku Kenkyusho Co., Ltd.

Humio Takaiwa

Takahito Jomori

Hiroyasu Ebinuma

Koichi Sugita

Yuji Hayashi

Akira Tashita

Saori Kasahara

Hiroshi Yasuda

The present invention is regarding plants and plant storage organs thereof in which GLP-1 derivatives are accumulated, and methods of producing them. The transgenic plants and plant storage organs thereof accumulate tandem repeated GLP-1 derivatives cleavable with intestinal digestive enzyme to monomeric molecules and are produced by methods comprising: integrating into vectors linked DNAs which comprise tandem repeated DNAs encoding the GLP-1 derivative with trypsin resistance in which the amino acid in the 26th position is Gln, the amino acid in the 34th position is Asn or Asp, and C-terminal consists of Arg or Lys to produce monomeric molecules; introducing the vectors into plant cells; and redifferentiating the obtained transformants. The edible transgenic plants and plant storage organs are useful for treating diabetes and can be ingested by diabetic patients.

Plant and plant storage organ having GLP-1 derivative accumulated therein and method of producing the same

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Tsukuba, Japan

Humio Takaiwa