National Institutes of Health, a Component of the US Dept. of Health & Human Services

Materials Modification Inc.

Humcha Krishnamurthy Hariprakasha

Tirumalai Srinivas Sudarshan

Christopher J Michejda

Krishnaswamy Kasthuri Rangan

Zoltan Szekely

Marek W Cholody

Krishnaswamy K Rangan

Disclosure of functionalized ionic liquids. Use of disclosed ionic liquids as solvent for carbon dioxide. Use of disclosed ionic liquids as flame retardant. Use of disclosed ionic liquids for coating fabric to obtain flame retardant fabric.

Functionalized ionic liquids and their applications

A conjugate of formula: V&#x2014;(Y)&#x2014;Z-T: (I), T-X&#x2014;B&#x2014;(Y)&#x2014;Z-T': (II), V&#x2014;(Y)Z&#x2014;(Y&#x2032;)V&#x2032;: (III), T-X&#x2014;B&#x2014;(Y)&#x2014;Z&#x2014;(Y&#x2032;)&#x2014;X&#x2032;&#x2014;B&#x2032;-T&#x2032;: (IV), V&#x2014;(Y)&#x2014;Z&#x2014;(Y&#x2032;)&#x2014;X&#x2014;B-T: (V), V&#x2014;(Y)&#x2014;Z&#x2014;X&#x2014;B&#x2014;Z&#x2032;&#x2014;(Y&#x2032;)&#x2014;(V&#x2032;): (VI), or (W)&#x2014;(Y)&#x2014;[(Z)&#x2014;(Y&#x2032;)&#x2014;(X&#x2014;B)&#x2014;(Y&#x2033;)&#x2014;(Z&#x2032;)]&#x2014;(Y . . . )&#x2014;(W&#x2032;): (VII), in which W and W&#x2032; are independently a DNA intercalator or terminal subunit, V and V&#x2032; are independently a DNA intercalator, X and X&#x2032; are independently a DNA alkylator, B and B&#x2032; are the same or different and each is a heteoaromatic residue that is attached to the Nterminus of an alkylator subunit (X or X&#x2032;), Y, Y&#x2032;, Y&#x2033; and Y&#x2032;&#x2033; are independently a linker, T and T&#x2032; are independently terminal subunits, Z and Z&#x2032; are independently a polyamide group that binds to the minor groove of DNA, a, b, c, d, f, g, i, and j are independently 0 to 5, and e and h are independently 1 to 5, a composition comprising a conjugate of any of formulae (I)-(VII) and a carrier, and a method for treating cancer in a mammal comprising administering an effective amount of a conjugate of any of formulae (I)-(VII) or a composition comprising same.

DNA-binding polyamide drug conjugates

Growing community of inventors

Frederick, MD, United States of America

Humcha Krishnamurthy Hariprakasha