China Agricultural University

Chinese Academy of Medical Sciences

Xinchang Pharmaceutical Factory, Zhejiang Medicine Co. Ltd.

Huiyuan Guo

Hao Zhang

Liang Zhao

Ran Wang

Bing Fang

Pengjie Wang

Yixuan Li

Xiaoxia Li

Jingjing He

Jiuyu Liu

Jing Zhan

A use of lactoferrin in the preparation of a food or drug, the food or drug being used for activating a VDR signaling pathway, which is used for the treatment of bone disease, bone disease comprising: osteoporosis, bone damage, loss of bone calcium, incomplete bone development and bone abnormalities. The present invention further comprises screening for drugs that are used to promote osteoblast proliferation and differentiation by using an active state of the VDR signaling pathway.

Study on lactoferrin regulation of bone formation by means of vitamin D receptor

A method for screeningfermentation agent is provided. The method is specifically implemented by screening astrain with high-expression of a lac cluster gene and no enzymatic activity of β-fructosidase. Thestrain that rapidly metabolizes lactose is screened through high expression of the lac cluster gene, such that the problem of large differences in acid production in fermented milk beverage products is avoided.

Method for screeningfermentation agent

This invention discloses novel quinolonecarboxylic acid derivatives, pharmaceutically acceptable salts or hydrates thereof, and their preparation methods and medical uses. The compounds in this invention show potent antibacterial activity against broad-spectrum pathogenic bacteria, with favorable pharmacokinetics and very low toxicity. The quinolinecarboxylic acid derivatives, which possess a hydrogen atom or an amino group at C-5 position, cis-substituted optical or racemic 2,8-diazo-dicyclo[4,3,0]nonanyl at C-7 position, and difluoromethoxyl at C-8 position of quinolone core, have superior activity against gram-positive bacteria and broad spectrum antibacterial activity compared with the known quinolones.

Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof

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Beijing, China

Huiyuan Guo