Genentech, Inc.

Rqx Pharmaceuticals, Inc.

F. Hoffmann-la Roche Ag

Genetech, Inc.

Huiyong Hu

Steven Huy Do

Aleksandr Kolesnikov

Xiaojing Wang

Jacob Bradley Schwarz

Wendy Lee

James John Crawford

Prasuna Paraselli

Robert Higuchi

Michael F T Koehler

Cuong Q Ly

Peter Andrew Smith

Vickie Hsiao-Wei Tsui

Emily J Hanan

Vickie H Tsui

Toby Jonathan Blench

Zhaoyang Wen

Tucker Curran Roberts

Philippe Bergeron

Yongsheng Chen

Paul Colin Michael Winship

Zhiyong Yu

Robert I Higuchi

Calum McCleod

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Macrocyclic broad spectrum antibiotics

Pyrazolo[3,4-c]pyridine compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein Rand Rare as defined herein, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. 

Pyrazolo[3,4-c]pyridine compounds and methods of use

5-Azaindazole compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. 

5-azaindazole compounds and methods of use

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Fremont, CA, United States of America

Huiyong Hu